Dr. Nawarathne earned her bachelor’s degree (First Class Honors) in chemistry from University of Colombo in Sri Lanka and her PhD in bioorganic chemistry from Michigan State University in East Lansing. For her dissertation research, she successfully utilized Taxus acyltransferases in biocatalysis in order to modify biologically important natural product scaffolds such as paclitaxel (Taxol®) under the supervision of Dr. Kevin D. Walker.
Upon graduation in 2011, she joined the College of Pharmacy at University of Michigan in Ann Arbor as a research fellow, where she gained medicinal chemistry skills by conducting research on antibiotic development. Her current research lab at Lyon College focuses on the development of efficacious therapeutics from large natural product scaffolds, with proven biomedical applications, through targeted synthesis.
Currently, her undergraduate research team is working on the development of novel rifamycins to combat multi-drug resistant Mycobacterium tuberculosis (MTB) strains by gaining a deeper understanding of molecular interactions between rifamycins and MTB RNA polymerase. In addition, a large part of her lab develops next generation therapeutics for lung cancer which happened to be the most common cancer type worldwide in terms of both incidence and mortality. Her laboratory also works on other small projects relevant to food chemistry and water quality.
Dr. Nawarathne is funded through the National Institutes of Health and General Medical Sciences (P20 GM103429). She is passionate about creating opportunities for undergraduate students to explore the process of drug discovery and challenging them with intriguing questions while contributing to the advancement of human health through drug discovery.
CHM 302 and CHM 302L – Advanced Inorganic Chemistry Lecture and Laboratory (4 credits)
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Nawarathne, I. N. Alkenes, Brought to You in Familiar Faces, J. Chem. Educ., 2022, 99, 3418–3423, DOI: 10.1021/acs.jchemed.2c00103
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Fox, M.; Newcomb, K.; Oliveira, C.; Shakiba, E.; Nawarathne, I. N. Facile analysis of rice bran oil to compare free unsaturated fatty acid compositions of parental and hybrid rice lines, J. Am. Oil Chem. Soc. (JAOCS) 2022, 1-9, DOI: 10.1002/aocs.12631
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Ford, A.; Miller, L.; Trant, J.; Nawarathne, I. N. A Minimalistic Approach to Single-Stranded DNA Circles, MethodsX , 2021, DOI: 10.1016/j.mex.2021.101300
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Nawarathne, I. N. Lyon College and the University of Arkansas Medical Sciences at Little Rock, Compositions and Methods of Use, 2020, U.S. Provisional Patent Application No. 63/042,255, Filed 06/22/2020
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Sullivan, S.; Nawarathne, I. N.; Walker, K. CoA Recycling by a Benzoate Coenzyme A Ligase in Cascade Reactions with Aroyltransferases to Biocatalyze Paclitaxel Analogs, Arch. Biochem. Biophys., 2020, 683, PMID: 31978400, DOI: 10.1016/j.abb.2020.108276
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Nawarathne, I. N. Introducing Diversity through an Organic Approach, J. Chem. Educ., 2019, 96, 2042-2049, DOI: 10.1021/acs.jchemed.8b00646
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Molodtsov, V; Nawarathne, I. N.; Scharf, N. T.; Kirchhoff, P. D.; Showalter, H. D. H.; Garcia, G. A.; Murakami, K. S. X-ray crystal structures of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycins, J. Med. Chem., 2013, 56, 4758-4763 PMCID: PMC3745299 (Featured in Cover Art Gallery, Volume 56)
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Showalter, H. D.; Garcia, G. A.; Xu, H.; Atwal, S. K.; Nawarathne, I. N.; Kirchhoff, P. D., The Regents of The University of Michigan (2013) Antimicrobial Compounds, WO/2013/086415
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Nawarathne, I. N.; Walker, K. D. Modification of Biologically Important Natural Product Scaffolds through Biocatalysis, Using Taxus Acyltransferases (A Review), Resonance Annual Magazine, University of Colombo, Sri Lanka, 2013, 100-104
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Nawarathne, I. N.; Walker, K. D. Point Mutations (Q19P and N23K) Increase the Operational Solubility of a 2α-O-Benzoyltransferase that Conveys Various Acyl Groups from CoA to a Taxane Acceptor, J. Nat. Prod., 2010, 73, 151-159 PMCID: PMC20108947
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Nevarez, D. M.; Mengistu, Y. A.; Nawarathne, I. N.; Walker, K. W. An N-Aroyltransferase of the BAHD Superfamily has Broad Aroyl CoA Specificity In Vitro with analogs of N-Dearoylpaclitaxel, J. Am. Chem. Soc., 2009, 131, 5994 – 6002 PMCID: PMC19382815
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Nawarathne, I. N.; Jayasekara, S.; De Silva, E. D. Investigation of Antifungal Activity of Drosera indica, Chemistry in Sri Lanka, 2005, 22, 189
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Perkins, N. A.; Beeser, L.; Beasley, I.; Jenkins, S. V.; Humphrey, M.; Tyler, R.; Smith, E.; Terlea. A. C.; Dings, R. P.; Nawarathne, I. N. Sequential Coupling of Michael Addition and Click Reaction Leads to the Advancement of Lung Cancer Therapy, 2022, In Preparation J. Med. Chem.
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Armstrong, D.; Beasley, I.; Fullerton, M.; Smith, J.; Crain, D.; Treadway, W.; Gopaul, C.; Milligan, H.; Dragan, A.; Voth, D. E.; Nawarathne, I. N. Modified Rifamycins Through the Coupling of Enabling Reaction with Click Chemistry, 2022, In Preparation J. Am. Chem. Soc.
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Trant, J.; Miller, L.; Mason, T.; Milligan, N.; Stout, M. G.; Bumpous, B.; Brineman, S.; Howell, S.; Nawarathne, I. N. Facile Synthesis of Key Rifamycin Analogues to Target the Most Prevalent Rifampin Resistant Mycobacterium tuberculosis RNA Polymerase, 2023, In Preparation J. Med. Chem.
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Beeser, B.; Humphrey, M.; Smith, E.; Perkins, N. A.; Jenkins, S. V.; Dings, R. P.; Voth, D.; Nawarathne, I. N. Efficient Synthesis and Isolation of Amino Acid Conjugates of 1,4-Naphthoquinone with Antimicrobial and Antineoplastic Properties, 2023, Manuscript in Preparation for J. Nat. Prod.
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Duty, T.; Sifford, J.; Staton, W.; Walker, K. D.; Nawarathne, I. N. Assessing the Timing of 2-O-Benzoylation Step in the Overall Paclitaxel Biosynthetic Pathway, 2023, Manuscript in Preparation for J. Nat. Prod.
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Azido, Alkyne, and Triazole Incorporated Rifamycin Derivatives Show Promising Biological Activities (Armstrong, D.; Smith, J.; Jenkins, S. V.; Dings, R. P.; Voth, D.; Nawarathne, I. N. Abstracts of Papers, ACS Spring National Meeting, April 5-16, 2021, MEDI)
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Comparison of Rice Bran Oil Composition Between Parental and Hybrid Lines (Fox, M.; Oliveira, C.; Shakiba, E.; Nawarathne, I. N. Abstracts of Papers, ACS Spring National Meeting, April 5-16, 2021, AGFD)
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Amino- and Amidonaphthoquinones Lead to Novel Lung Cancer Therapeutics (Perkins, N. A.; Humphrey, M.; Smith, E.; Ho, K.; Jenkins, S. V.; Dings, R. P.; Nawarathne, I. N. Abstracts of Papers, ACS Spring National Meeting, April 5-16, 2021, MEDI)
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Modification of hydroxynaphthoquinone scaffold in search of antimicrobial and antineoplastic agents (Smith, E.; Maloney, T.; Humphrey, M.; Ray, C.; Nawarathne, I. N. Abstracts of Papers, ACS National Meeting, Orlando, FL, United States, March 31-April 4, 2019, MEDI-192)
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TB or not TB? That is not the only question (Trant, J.; Milligan, N.; Ford, A.; Hodge, Z.; Nawarathne, I. N. Abstracts of Papers, ACS National Meeting, Orlando, FL, United States, March 31-April 4, 2019, MEDI-356)
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Studies directed toward the design of benzoxazinorifamycins less susceptible to emerging resistance (Nawarathne, I. N.; Scharf, N. T.; Molodtsov, V.; Kirchhoff, P. D.; Murakami, K. S.; Garcia, G. A.; Showalter, H. D. H. Abstracts of Papers, 247th ACS National Meeting, Dallas, TX, United States, March 16-20, 2014, MEDI-156)
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Pinpointing the timing of 2-​O-​benzoylation in the overall paclitaxel biosynthetic pathway (Nawarathne, I. N.; Walker, K. D. Abstracts of Papers, 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 19-23, 2012, BIOL-201)
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Utilizing Taxus acyltransferases as biocatalysts: A handy way of producing modified paclitaxel compounds (Nawarathne, I. N.; Walker, K. D. Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010, BIOL-86)
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Point mutations (Q19P and N23K) increase the operational solubility of a 2-O-benzoyltransferase that conveys various acyl groups from CoA to a taxane acceptor (Nawarathne, I. N.; Walker, K. D. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010, BIOT-454)
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N-Benzoyltransferase has broad aroyl CoA specificity in vitro with analogs of N-debenzoylpaclitaxel (Nevarez, D. M.; Mengistu, Y. A.; Nawarathne, I. N.; Walker, K. W. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010, BIOL-117)
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Oral presentation on “Simple Click Chemistry on Complex Rifamycin Core Leads to Novel Antimicrobials” (Smith, J.; Treadway, W.; Proctor, A.; Armstrong, D.; Fullerton, M.; Dragan, A.; Voth, D. E.; Nawarathne, I. N.) and poster presentations on “Aminonaphthoquinones Show Activity against Lung Cancer Cell Lines” (Perkins, N. A.; Tyler, R.; Harness, H.; Jenkins, S. V.; Fullerton, M.; Dragan, A.; Voth, D. E.; Dings, R. P.; Nawarathne, I. N.), “Biological Significance of Comparable Amino- and Amidonaphthoquinones” (Beeser, L.; Terlea, A. C.; Jenkins, S. V.; Dings, R. P.; Nawarathne, I. N.), and “Unraveling the Health Implications of Modified Sucralose” (Beasely, I.; Nawarathne, I. N.) at the Student Creative Arts and Research Forum (SCARF), Batesville, AR, May 15, 2022 (Presentations won the First Place Award in Oral Category and the First and Second Place Awards in Poster Category)
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Poster presentations on “Comparison of Composition of “Healthy Oil” from Selected Parental and Hybrid Rice Lines” (Nawarathne, I. N.; Fox, M.; Oliveira, C.; Shakiba, E.), “Simple Click Chemistry on Complex Rifamycin Core Leads to Novel Antimicrobials” (Smith, J.; Crain. D.; Milligan, H.; Armstrong, D.; Fullerton, M.; Dragan, A.; Voth, D. E.; Nawarathne, I. N.), “Aminonaphthoquinones Containing Azido, Alkyne, and Triazole Moieties Show Activity against Lung Cancer Cell Lines” (Perkins, N. A.; Humphrey, M.; Jenkins, S. V.; Fullerton, M.; Dragan, A.; Voth, D. E.; Dings, R. P.; Nawarathne, I. N.), “8-Deoxyrifamycin S, a New Solution to an Old Problem: Multi-Drug Resistant Tuberculosis” (Gopaul, C.; Beasley, I.; Mason, T.; Fullerton, M.; Dragan, A.; Voth, D. E.; Nawarathne, I. N.), “Biological Significance of Comparable Amino- and Amidonaphthoquinones” (Beeser, L.; Jackson, T.; Smith, E.; Humphrey, M.; Jenkins, S. V.; Dings, R. P.; Nawarathne, I. N.), and “Unraveling the Health Implications of Modified Sucralose” (Crain, D.; Jorgensen, M.; Mason, T.; Nawarathne, I. N.) at the Southeast Regional IDeA Conference, San Juan, Puerto Rico, November 12-14, 2021.
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Poster presentations on “Amino- and amidonaphthoquinones lead to novel lung cancer therapeutics” (Perkins, N.; Smith, E.; Jackson, T.; Nawarathne, I. N.) and “Synthesizing New Drug Compounds to Fight Multidrug Resistant Tuberculosis” (Smith, J.; Milligan, H.; Nawarathne, I. N.) at the Student Creative Arts and Research Forum (SCARF), Batesville, AR, April 28, 2021 (Each poster won the First and Second Place Best Poster Presentation Award respectively)
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Oral presentations on “Modified Michael Addition Leads to Biologically Significant Naphthoquinones” (Perkins, N. A.; Ho, K.; Humphrey, M.; Smith, E.; Jenkins, S. V.; Dings, R. P.; Nawarathne, I. N.), “Extraction and Quantification of Polyunsaturated Fats in Rice Bran” (Fox, M.; Oliveira, C.; Shakiba, E.; Nawarathne, I. N.), and “Unraveling the Health Implications of Modified Sucralose” (Jorgensen, M.; Mason, T.; Nawarathne, I. N) at the Arkansas INBRE 2020 Conference, November 6-7, 2020
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Flash talks and poster presentations on “Modified Michael Addition Leads to Biologically Significant Naphthoquinones” (Humphrey, M.; Smith, E.; Maloney, T.; Jenkins, S. V.; Dings, R. P.; Nawarathne, I. N.) and “Development of Efficacious Rifamycin Derivatives by Utilizing Click Chemistry” (Hodge, Z.; Armstrong, D.; Nawarathne, I. N) at the Southeast Regional IDeA Conference, Louisville, KY, November 6-8, 2019
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Oral presentation on “Fighting Drug-resistant Mycobacterium tuberculosis with Modified Rifamycins” (Trant, J.; Nawarathne, I. N.) at the Arkansas INBRE 2018 Conference in Fayetteville, November 2-3, 2018 (Student won the 2018 First Place Chemistry Oral Presentation Award)
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Poster presentations on “Utilization of Click Chemistry to Modify Hydroxynaphthoquinone Scaffolds to Develop Efficacious Drug Leads” (Smith, E.; Hodge, Z.; Nawarathne, I. N.) and “Development of Key Rifamycin Analogues to Target Prevalent Multi-Drug Resistant Mycobacterium tuberculosis” (Nawarathne, I. N.; Trant, J.; Miller, L.; Bumpous, B.; Milligan, N.; Stout, M. G.; Brineman, S.; Howell, S.) at the Sixth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE) in Washington, DC, June 24-26, 2018
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Oral presentation on “Fighting Drug-resistant Mycobacterium tuberculosis with Modified Rifamycins” (Trant, J.; Miller, L.; Nawarathne, I. N.) at the Alpha Chi Academic Honor Society Convention Portland, OR, April 5-7, 2018 (Student won Joseph E. and Bessie May Prior Prize in Chemistry for research)
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Oral presentation on “Fighting Drug-resistant Mycobacterium tuberculosis with Modified Rifamycins” (Trant, J.; Miller, L.; Nawarathne, I. N.) at the Student Creative Arts and Research Forum (SCARF), Batesville, AR, March 22, 2018 (Student won the Best Oral Presentation Award)
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Poster presentations on “Impact of Arkansas INBRE on Undergraduate Teaching and Research at Lyon College” (Nawarathne, I. N.), “Fighting Drug Resistant Mycobacterium tuberculosis with Modified Rifamycins” (Trant, J.; Miller, L.; Nawarathne, I. N.), “Probing Interactions of Rifamycins and Mycobacterium tuberculosis RNA Polymerases” (Bumpous, B.; Nawarathne, I. N.), and “Utilizing a Mutated Taxus Benzoyltransferase as a Biocatalyst” (Duty, T.; Sifford, J.; Nawarathne, I. N.), at the Southeast Regional IDeA Conference, Morgan Town, WV, October 11-13, 2017.
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Oral presentation on “Finding Novel Treatments for Tuberculosis Using Deoxygenation Reactions” (Miller, L.; Nawarathne, I. N.) at the 4th Annual Drug Discovery and Development Colloquium (DDDC), Little Rock, AR, June 15-17, 2017 (Only undergraduate oral presentation in the conference; also won the Research Excellence Award)
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Poster presentation on “Fighting Drug Resistant Mycobacterium tuberculosis with Modified Rifamycins” (Miller, L.; Trant, J.; Mullins, D.; Wight, S.; Nawarathne, I. N.) at the Sixth Annual Central Arkansas Undergraduate Summer Research Symposium (CAUSRS), Little Rock, AR, July 26th, 2017 (Student won a Research Excellence Award).
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Oral presentation on “Fighting Drug Resistant Mycobacterium tuberculosis with Modified Rifamycins” (Trant, J.; Miller, L.; Nawarathne, I. N.), Alpha Chi Academic Honor Society Convention, Louisville, KY, April 6-8, 2017.
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Poster presentation on “Introducing Diversity through an Organic Approach” (Nawarathne, I. N.; et al.) at the Global Conference on Education and Research in Sarasota, FL, May 22-25, 2017 (twenty students from 2016/2017 organic class are co-authors of the abstract)
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Oral presentation on “Utilizing a Mutated Taxus Benzoyltransferase (mTBT) as a Biocatalyst” (Staton, W.; Nawarathne, I. N.) at the Arkansas INBRE 2016 Conference at Fayetteville Town Square and University of Arkansas Campus in Fayetteville, October 21-22, 2016
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Oral presentation on “Probing Interactions of Rifamycins and Mycobacterium tuberculosis RNA Polymerases” (Bumpous, B.; Stout, M. G.; Nawarathne, I. N.) at the Fifth Annual Central Arkansas Summer Undergraduate Research Symposium (CAUSRS), University of Arkansas for Medical Sciences, Little Rock, AR, July 20th, 2016
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iPoster presentations on “Probing Interactions of Rifamycins and Mycobacterium tuberculosis RNA Polymerases” (Nawarathne, I. N.; Brineman, S.; Bumpous, B.; Howell, S.) and “Fighting Drug Resistant Mycobacterium tuberculosis with Modified Rifamycins” (Hanes, L.; Staton, W.; Stout, M. G.; Trant, J.; Nawarathne, I. N.) at the Sixth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE) in Washington, DC, United States, June 25-28, 2016
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Invited research talks on “TB or not TB? That is not the only question” (Nawarathne, I. N.) at the Department of Chemistry and Biochemistry in the University of Wisconsin, Eau Claire, WI, December 6th, 2021, and at the Department of Chemistry in the Moravian University, Bethlehem, PA, December 8th, 2021
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Invited webinar on “Using Benchtop NMR in Biomedical Research and Teaching” (Nawarathne, I. N.) at the virtual Spinsolve User's Webinar organized by Magritek Inc., Malvern, PA, August 4th, 2021
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Invited virtual talk on “Actions Vs Words to Liberate Women Chemists” (Nawarathne, I. N.) at the Women Chemists Committee (WCC) session in the Annual Sessions of Institute of Chemistry Ceylon, Sri Lanka, June 29th, 2021
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Invited virtual research talk on “TB or not TB? That is not the only question” (Nawarathne, I. N.) initiating the Research Talk Series of the Department of Chemistry in University of Colombo, Sri Lanka, November 18th, 2020
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Invited virtual research talk on “TB or not TB? That is not the only question” (Nawarathne, I. N.) at the 2020 Virtual Drug Discovery Symposium organized by SBA School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan, August 8th, 2020
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Invited virtual research talk on “TB or not TB? That is not the only question” (Nawarathne, I. N.) at the Arkansas Summer Research Institute (ASRI) in Hot Springs, AR, July 23rd, 2020
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Invited research talk on “TB or not TB? That is not the only question” (Nawarathne, I. N.) at the Biology and Chemistry Colloquium Series, Arkansas State University, Jonesboro, AR, September 18th, 2019
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Invited plenary talk at the Arkansas INBRE 2018 Conference on “TB or not TB? That is not the only question” (Nawarathne, I. N.) at the Chancellor Hotel and University of Arkansas Campus in Fayetteville, AR, November 2-3rd, 2018
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Invited research talk on “TB or not TB? That is not the only question” (Nawarathne, I. N.) for the Organic Seminar Series and Alumni Talk Highlight at the Department of Chemistry, Michigan State University, East Lansing, MI, October 17th, 2018
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Seminar and discussion on “First Year at a Liberal Arts College” (Nawarathne, I. N.) for the Teaching Circle of University of Michigan Postdoctoral Association (UMPDA), The University of Michigan, Ann Arbor, MI, December 15th, 2015